Imaging P2X4 Receptor Lateral Mobility in Microglia

Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin

P2X4 receptors are adenosine triphosphate (ATP)-gated cation channels present on the plasma membrane (PM) and also within intracellular compartments such as vesicles, vacuoles, lamellar bodies (LBs), and lysosomes. P2X4 receptors in microglia are up-regulated in epilepsy and in neuropathic pain; that is to say, their total and/or PM expression levels increase. However, the mechanisms underlying...

Microglia in amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis is a neurodegenerative disorder that results in the selective death of motor neurons in the central nervous system. This progressive motor neuron degeneration leads to death of the patient on average three to five years after onset of the disease. To date, no therapy is available. Many hypotheses have been formulated to explain the selective degeneration of motor n...

magnetic resonance imaging in dentistry

چکیده ندارد.

T cell adhesion mechanisms revealed by receptor lateral mobility.

Cell surface receptors mediate the exchange of information between cells and their environment. In the case of adhesion receptors, the spatial distribution and molecular associations of the receptors are critical to their function. Therefore, understanding the mechanisms regulating the distribution and binding associations of these molecules is necessary to understand their functional regulatio...

AFM imaging reveals the assembly of a P2X receptor complex containing P2X2, P2X4 and P2X6 subunits